???5?????????

?????????5?????????????????????????5??.TW??????????????????????????????????????????????????

?????5???10?20??????

??????????????????????????????5???????????5????????????????????????? 2.5 ? 20 ???????????(AUC)??????(???)???????????????(17.5??)?????????????????????5??????? 5 ??????????????????????????????? 1.6 ?????????????8??????

??,???5???????????,???????? - ??:??????????????????

????????

1.??????????????????,?????,??????

2.??????????????,???????????

???????? (??????????)

?:?????5??,????,??????,??????????????,??????????

?:???5???????????,?????????,?????,???????,?????????,?????

??: ???????????

????????????????????(Cmax)??????? 30 ??? 6 ???(???? 2 ??)?????????????30???2????????????5??????????8????????????????????????????????????????????????????????????????



?????5????????

???????????????????5?????????????????????????????????????????????????????5????5?????????????????????8??????????????????????30????????10???

???????????????5???????????50?? ?????????????????????????????????????????????1?

?????, ???????????????????????????????????????????????????????????????????????????48????????????????

??????????????????????????????????????????????????5??????????????????????????????????????????????????????????

????????

?????????????????< 30 mL/min???????????????????tadalfil????

(1)???90?????????

(2)??????????????????????

(3)???6???????????????????????????

(4)???????????????(<90/50????)??????????

(5)??6?????????

???

??????=??????250????????5%???

?????100????????12%????

???????30????????40%???

?????

Efficacy and safety of long-term tadalafil 5 ?? once daily combined with sildenafil 50 ?? as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2015 Feb;47(1):20-4.