??????????????????

???5mg????,??????????????

?????????????  Tadalafil ???????????????????????????????????????????????????????????????????5MG.TW????????5mg???????????????????????

?????  Tadalafil ???????????

??????????????,??????????????50?????????????????????(???)??????????????????????????????????????????????????????????????????????????????????????????(????????????)????????????????????????????????????????????????????????????????????????

??? Tadalafil ?2003????????????????????????????????????????????????????????????????????????36??????????????????

??2011?10?????????????????????FDA????????????????5??????????????????????????????????????????????????????????????

??????5mg??????????????????????????????

(1)??NO/cGMP??

(2)?????????????

(3)??????

(4)???????????????

(5)??Rho-kinase???1??

??????????(??J?K)?2,3????????(??L)?4???????????????????5?????? ????????????IPSS??1????IPSS?????K?L????????????(?4?)??2????????????12???????????5???12????????????????????????????????????????









?1?IPSS(International Prostate Symptom Score,??????????)?IPSS ????????????????????????????????????? ?????????IPSS???????(????????)????(????? ???????????????????)??????????0?35????? ?????????

????????????????????????

??????????????????????????Tadalafil ?????????????????????(??Alfuzosin, Doxazosin, Tamsulosin ? Terazosin)?5? ??????(??Finasteride ? Dutasteride)?

??????????????Finasteride???????????????????????????????????????????????????????????????(???????????)?????

?????????Finasteride???????????Finasteride??????????????????????????????????(?12??total IPSS)?????????????total IPSS??????????????4??????????-4.0,placebo-2.3:p<.001)??26??????????-5.5,placebo-4.5;p=.022)?5??????????????Finasteride?????Finasteride??????????????????????????Finasteride??????????????



???????????

?????????????????????5mg????????????????????????(????,???,???,??????????)???????????

????????????????5????5?????????????????????8??????????????????????30-60????????10mg????????????????5???????????50?? ??????????????????????????????????????????6??

???????? ??????????????????????????????????????????????????????????????????????????????48????????????????(??????????????)

????????????: ???Viagra,???P-Force,???KAMAGRA,???Oral Jelly

????????????: ???

????????????: ???

????????: http://www.krrista.com/category.php?id=1

?????

1.A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Ther Adv Urol. 2014 Aug; 6(4): 135�147.

2.??J?Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study. J Urol. 2008 Oct; 180(4):1228-34.

3.??K: Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of a multinational randomized, double�blind, placebo�controlled trial. Eur Urol. 2011;60:1105�1113.

4.??L:Tadalafil once daily for lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a randomized placebo- and tamsulosin-controlled 12-week study in Asian men. Int J Urol. 2013 Feb; 20(2):193-201.

5.Efficacy and safety of the coadministration of tadalafil once daily with finasteride for 6 months in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia. J Urol. 2014 Mar;191(3):727-33. 

6.Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2015 Feb;47(1):20-4.