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??????????????????5?PDE-5???????????????ED??????? PDE-5??????????????????5?PDE-5??????????PDE-5?????????????????????????NO????????????????????????????????
NO/cGMP??????? ??????????????????????????NO??NO???????????cGMP????????????cGMP??????cGMP????????????????????????? PDE-5??? ???PDE-5??????cGMP???????????????????PDE-5???????????PDE-5???????cGMP?????cGMP???????????????NO/cGMP?????????????? ??PDE-5???????? ??PDE-5????????????????????????????????????Sildenafil???????Tadalafil???????Vardenafil???????????????????????????????????? PDE-5???????? PDE-5???????????ED???????????????????????PDE-5?????????????????????????????? PDE-5???????PDE-5???????cGMP?????????NO/cGMP???????????????????????????ED???????????????????????????PDE-5????????????????? ????? Francis, S. H., & Corbin, J. D. (2002). PDE-5 inhibition: Chemistry and potential for drug development. Current pharmaceutical design, 8(19), 371-388. Kloner, R. A. (2011). Cardiovascular risk and PDE-5 inhibitors: therapy for erectile dysfunction. Journal of andrology, 32(6), 541-546. |
