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??????? 1???????? ???????????????????????????????-5?PDE5???????????????????????????????????????????????????????????????????????????????????????????????????????? 2????????PAH????? ???????????????????????????PAH??PAH???????????????????????????????????????????????????????????????????????????????????? 3????????????? ????????????????????????????????????????????????????????????????????????????????????? 4??????????? ???????????????????????????????????????????????????????????????????????????????????? 5?aynaud????? Raynaud??????????????????????????????????????????????????Raynaud?????????????? 6???????? ???????????????????????????????????????????????????????????????? ????????????????????????????????????????????????????????????????????Raynaud???????????????
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????? 1.Kloner, R. A. (2011). Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation, 124(8), 967-972. 2.Ghofrani, H. A., Osterloh, I. H., Grimminger, F. (2006). Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nature Reviews Drug Discovery, 5(8), 689-702. |
