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???????Erectile
Dysfunction???ED???????????????????????????????????????????ED???????????????????????????
????????? 1.??????????? ????????????Phosphodiesterase type 5 inhibitors?PDE5????????????????????????Sildenafil??????Tadalafil???????????PDE5?????????NO?????????????????????? ????Sildenafil?? ?????????????ED??????????????????????4?????????30???1????????????????????80%??? ????Tadalafil?? ????????????????????36??????????????????????????????????????????????????????????????????????????????????
2.???????? ????????Prostaglandin E1?PGE1???????????????????????Alprostadil????????????????????????????? ?????Alprostadil?? ??????????????????????????????????????????????????????????????15??????????????????????????????????70%??? ?????????????????????????????????????????PDE5?????????????????????????????????????????????? ???????????????????????????????????????????????????????????????????? ????? 1.Goldstein I, et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 1998;338(20):1397-404. 2.Porst H, et al. Efficacy of Alprostadil cream in the treatment of erectile dysfunction: a double-blind, placebo-controlled study. J Urol. 2003;170(1):255-8. |
