??????????????
2014?2?Nature reviews
Urology??????????PDE5????????????????????????????????????60????3?????????????????????????????????????????????(??????)?????PDE5???TADALAFIL
TADARISE-5?2???
???????????(IIEF-5)?????TADALAFIL????????????????????????????????(MMSE)??????????????????????????????????????-9(PHQ-9)?????????PHQ-15????????????TADALAFIL??????????????
????????(phosphodiesterase type 5,
PDE5)??????????????????????????1998?????????????(FDA)?????????????????????,???,?????????????
???????????????????????????????(NO)??GTP?????GMP (cGMP)?cGMP????????????????????????????????cGMP??PDE????????????PDE5?????????????
?????????(???5mg??FDA??)???????????????????????????????
2014?2?Nature reviews
Urology??????????PDE5????????????????????????????????????60????3?????????????????????????????????????????????(??????)?????PDE5???TADALAFIL
TADARISE-5?2???
???????????(IIEF-5)?????TADALAFIL????????????????????????????????(MMSE)???????????????????(Forward
Digit-Span Task)???????????????????-9(PHQ-9)?????????PHQ-15????????????TADALAFIL
TADARISE-5??????????????
??TADALAFIL??????????????????????
???PDE5?????????(glutamate)?????(NO)-cGMP???????????????????????????cGMP?????????????????
???cGMP????????PDE???????????????????????????????????
????????????????????????????????????????????????????????????????????????????????
????:
Clyne M. Sexual dysfunction: Can PDE5 inhibitors boost brain function? Nat Rev
Urol. 2014 Feb;11(2):65.
Shim YS1, Pae CU, Cho KJ, Kim SW, Kim JC, Koh JS. Effects of daily low-dose
treatment with phosphodiesterase type 5 inhibitor on cognition, depression,
somatization and erectile function in patients with erectile dysfunction: a
double-blind, placebo-controlled study. Int J Impot Res. 2013 Nov 28. doi:
