1.1????:????????,???????????:
????????,??????????????,???????xx??
??????,?????,?????????,?????,???????????????????
????,???????????
???????,??????????????????????????????,?????????????,???????????????????????????
1.2????:????????,?????xy,???????????,????
1.3???????????:???????????????,?????????????????????????????????????????????????????????????????????11-oxos???????????????,?????x?????????
2?????????
2.1????,?????????????????????????
2.2???????????????,??????????????????????????
2.3???????????????????????????????,???????????????????????,??????????????????
3?????????
3.1???????????????,????,??,??,????,????,????,????,????,????,????,????,????,????,????,???????,?????????????????,???????
3.2?????????????????,????,???????,????,????,????,????,?????,????,????,??????,???,??????????,?????????????????,???????
1?????????????,?????????????????,??????????????????????????,??????????????????,?????????
2?????????????????????????,??????????????,????????,?????????????????,????????,????????,??????????
3?????????????,??????????????,???????????????,?????????????????????????,????????????,??????????
1???
?????????????,???????????40???,??????????
2?????
???????????????,?????????????
3????
???????????????????????,??????,????,??????????????????
4????
????,??????????????????????????????,?????????????????,?????
5????
???,????????????,??160?/min,????,?????????,??????????????????????????,???Sheehan????????????????????????????????????;??????????,????????????????????????????????4h,1/3?2/3??????24?48h????